Immunomodulatory and Antitumor Activities of Polysaccharide from Chinese White Wax Scale

FENG Ying; HE Zhao; LI Xian; CHENG Zhi-yong; SUN Long

Volume 27 Issue 3

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Immunomodulatory and Antitumor Activities of Polysaccharide from Chinese White Wax Scale

1.
Research Institute of Resources Insects, Chinese Academy of Forestry
2.
Laboratory of Cultivation and Utilization of Resource Insects, State Forestry Administration, Kunming 650224, Yunnan, China

Received Date: 2013-12-21

Abstract

The immunomodulatory and antitumor activities of crude polysaccharide (Cwps) and purified polysaccharide(Pwps)extracted from Chinese white wax scale were investigated in vivo and in vitro. The immunomodulatory effect of Cwps and Pwps were evaluated by carbon particle clearance index, thymus index and spleen index in cyclophosphamide-induced immunosuppressed mice. The inhibition rates of Chinese white wax scale polysaccharide on sarcoma 180 tumor in vivo and human leukemia, lung cancer, gastric cancer and hepatoma cell lines in vitro were observed. The results showed that both the Cwps and Pwps could increase phagocytic index significantly, but had no influence on thymus index and spleen index. The growth of S180 cell was significantly inhibited by Cwps in vivo, but both Cwps and Pwps didn't exhibited direct cytotoxic activities for four kinds tested tumor cells in vitro. The result indicated that antitumor properties of Chinese white wax scale polysaccharide might be achieved by improving immune response in vivo.
- Chinese white wax scale,
- polysaccharide,
- immunomodulatory,
- antitumor

References

[1]	谢明勇,聂少平. 天然产物活性多糖结构与功能研究进展[J]. 中国食品学报, 2010, 10(2): 1-11
[2]	Synytsya A, Novák M. Structural diversity of fungal glucans[J]. Carbohydrate Polymers, 2013, 92(1): 792-809
[3]	Kang M, Kim S Y, Kim Y T, et al. In vitro and in vivo antioxidant activities of polysaccharide purified from aloe vera (Aloe barbadensis) gel[J]. Carbohydrate Polymers, 2014, 99(2): 365-371
[4]	Cai W, Xie L, Chen Y, et al. Purification, characterization and anticoagulant activity of the polysaccharides from green tea[J]. Carbohydrate Polymers, 2013, 92(2): 1086-1090
[5]	Xie F, Sakwiwatkul K, Zhang C, et al. Atractylodis macrocephalae Koidz. polysaccharides enhance both serum IgG response and gut mucosal immunity[J]. Carbohydrate Polymers, 2013, 91(1): 68-73
[6]	Ai S, Fan X, Fan L, et al. Extraction and chemical characterization of Angelica sinensis polysaccharides and its antioxidant activity[J]. Carbohydr Polym, 2013, 94(2): 731-736
[7]	Jin M, Huang Q, Zhao K, et al. Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L.[J]. International Journal of Biological Macromolecules, 2013,54(3): 16-23
[8]	Schepetkin I A, Quinn M T. Botanical polysaccharides: macrophage immunomodulation and therapeutic potential[J]. Int Immunopharmacol, 2006, 6(3): 317-333
[9]	殷涌光,韩玉珠,丁宏伟. 动物多糖的研究进展[J]. 食品科学, 2006,27(3): 256-263
[10]	黄林清,周世文,张诗平,等. 蚕蛹多糖对小鼠免疫功能的影响[J]. 解放军药学学报, 2002, 18(1): 11-13
[11]	藏其中,万淑莹. 蚕蛹多糖的分离和分析[J]. 中成药, 1992, 14(3): 35-36
[12]	孙龙,冯颖,何钊,等. 蚕蛹多糖的碱液提取及免疫活性初步研究[J]. 林业科学研究, 2007, 20(6): 782-786
[13]	孙龙,冯颖,何钊,等. 蟑螂水溶性多糖提取、分析及免疫活性研究[J]. 林业科学研究, 2009, 22(2): 256-261
[14]	何钊,冯颖,孙龙,等. 黄粉虫多糖响应面法提取及抗氧化活性[J]. 食品与生物技术学报, 2011(5): 641-647
[15]	金伟,王亚威. 虻虫抗凝血物质的药理研究[J]. 中医药信息, 2000, 17(3): 64-66
[16]	陈晓鸣,冯颖. 资源昆虫学概论[M]. 北京: 科学出版社, 2009:29-30
[17]	冯颖,陈晓鸣,马艳,等. 白蜡虫免疫调节作用试验研究[J]. 林业科学研究, 2006,19(2): 221-224
[18]	冯颖,陈晓鸣,何钊,等. 白蜡虫抗突变实验与主要功效成分分析[J]. 林业科学研究, 2006, 19(3): 284-288
[19]	何钊,孙龙,冯颖,等. 白蜡虫多糖的提取及单糖组分分析[J]. 林业科学研究, 2008, 21(6): 792-796
[20]	Zhang M, Cui S W, Cheung P C K, et al. Antitumor polysaccharides from mushrooms: a review on their isolation process, structural characteristics and antitumor activity[J]. Trends in Food Science & Technology, 2007, 18(1): 4-19
[21]	Zhang Y, Li S, Wang X, et al. Advances in lentinan: Isolation, structure, chain conformation and bioactivities[J]. Food Hydrocolloids, 2011, 25(2): 196-206
[22]	Ng T B. A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae)[J]. Gen Pharmacol, 1998, 30(1): 1-4
[23]	Sun Y. Structure and biological activities of the polysaccharides from the leaves, roots and fruits of Panax ginseng C.A. Meyer: An overview[J]. Carbohydrate Polymers, 2011, 85(3): 490-499
[24]	Wang B, Won S, Yu Z, et al. Free radical scavenging and apoptotic effects of Cordyceps sinensis fractionated by supercritical carbon dioxide[J]. Food and Chemical Toxicology, 2005, 43(4): 543-552
[25]	Xu H, Zhang Y, Zhang J, et al. Isolation and characterization of an anti-complementary polysaccharide D3-S1 from the roots of Bupleurum smithii[J]. International Immunopharmacology, 2007, 7(2): 175-182
[26]	Rios J L. Chemical constituents and pharmacological properties of Poria cocos[J]. Planta Med, 2011, 77(7): 681-691
[27]	Jin M, Zhao K, Huang Q, et al. Isolation, structure and bioactivities of the polysaccharides from Angelica sinensis (Oliv.) Diels: A review[J]. Carbohydrate Polymers, 2012, 89(3): 713-722
[28]	毛俊浩,吕志良. 白术多糖对小鼠淋巴细胞功能的调节[J]. 免疫学杂志, 1996, 12(4): 233-236
[29]	汤新慧. 白术多糖对小鼠免疫功能的影响[J]. 中医研究, 1998, 11(2): 7-9
[30]	孟慧玲,魏道武. 当归多糖的药理学研究新进展[J]. 甘肃中医, 2007, 20(1): 44-46

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Immunomodulatory and Antitumor Activities of Polysaccharide from Chinese White Wax Scale

1. Research Institute of Resources Insects, Chinese Academy of Forestry

2. Laboratory of Cultivation and Utilization of Resource Insects, State Forestry Administration, Kunming 650224, Yunnan, China

Received Date: 2013-12-21

Abstract: The immunomodulatory and antitumor activities of crude polysaccharide (Cwps) and purified polysaccharide(Pwps)extracted from Chinese white wax scale were investigated in vivo and in vitro. The immunomodulatory effect of Cwps and Pwps were evaluated by carbon particle clearance index, thymus index and spleen index in cyclophosphamide-induced immunosuppressed mice. The inhibition rates of Chinese white wax scale polysaccharide on sarcoma 180 tumor in vivo and human leukemia, lung cancer, gastric cancer and hepatoma cell lines in vitro were observed. The results showed that both the Cwps and Pwps could increase phagocytic index significantly, but had no influence on thymus index and spleen index. The growth of S180 cell was significantly inhibited by Cwps in vivo, but both Cwps and Pwps didn't exhibited direct cytotoxic activities for four kinds tested tumor cells in vitro. The result indicated that antitumor properties of Chinese white wax scale polysaccharide might be achieved by improving immune response in vivo.

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Reference (30)

[1]	谢明勇,聂少平. 天然产物活性多糖结构与功能研究进展[J]. 中国食品学报, 2010, 10(2): 1-11
[2]	Synytsya A, Novák M. Structural diversity of fungal glucans[J]. Carbohydrate Polymers, 2013, 92(1): 792-809
[3]	Kang M, Kim S Y, Kim Y T, et al. In vitro and in vivo antioxidant activities of polysaccharide purified from aloe vera (Aloe barbadensis) gel[J]. Carbohydrate Polymers, 2014, 99(2): 365-371
[4]	Cai W, Xie L, Chen Y, et al. Purification, characterization and anticoagulant activity of the polysaccharides from green tea[J]. Carbohydrate Polymers, 2013, 92(2): 1086-1090
[5]	Xie F, Sakwiwatkul K, Zhang C, et al. Atractylodis macrocephalae Koidz. polysaccharides enhance both serum IgG response and gut mucosal immunity[J]. Carbohydrate Polymers, 2013, 91(1): 68-73
[6]	Ai S, Fan X, Fan L, et al. Extraction and chemical characterization of Angelica sinensis polysaccharides and its antioxidant activity[J]. Carbohydr Polym, 2013, 94(2): 731-736
[7]	Jin M, Huang Q, Zhao K, et al. Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L.[J]. International Journal of Biological Macromolecules, 2013,54(3): 16-23
[8]	Schepetkin I A, Quinn M T. Botanical polysaccharides: macrophage immunomodulation and therapeutic potential[J]. Int Immunopharmacol, 2006, 6(3): 317-333
[9]	殷涌光,韩玉珠,丁宏伟. 动物多糖的研究进展[J]. 食品科学, 2006,27(3): 256-263
[10]	黄林清,周世文,张诗平,等. 蚕蛹多糖对小鼠免疫功能的影响[J]. 解放军药学学报, 2002, 18(1): 11-13
[11]	藏其中,万淑莹. 蚕蛹多糖的分离和分析[J]. 中成药, 1992, 14(3): 35-36
[12]	孙龙,冯颖,何钊,等. 蚕蛹多糖的碱液提取及免疫活性初步研究[J]. 林业科学研究, 2007, 20(6): 782-786
[13]	孙龙,冯颖,何钊,等. 蟑螂水溶性多糖提取、分析及免疫活性研究[J]. 林业科学研究, 2009, 22(2): 256-261
[14]	何钊,冯颖,孙龙,等. 黄粉虫多糖响应面法提取及抗氧化活性[J]. 食品与生物技术学报, 2011(5): 641-647
[15]	金伟,王亚威. 虻虫抗凝血物质的药理研究[J]. 中医药信息, 2000, 17(3): 64-66
[16]	陈晓鸣,冯颖. 资源昆虫学概论[M]. 北京: 科学出版社, 2009:29-30
[17]	冯颖,陈晓鸣,马艳,等. 白蜡虫免疫调节作用试验研究[J]. 林业科学研究, 2006,19(2): 221-224
[18]	冯颖,陈晓鸣,何钊,等. 白蜡虫抗突变实验与主要功效成分分析[J]. 林业科学研究, 2006, 19(3): 284-288
[19]	何钊,孙龙,冯颖,等. 白蜡虫多糖的提取及单糖组分分析[J]. 林业科学研究, 2008, 21(6): 792-796
[20]	Zhang M, Cui S W, Cheung P C K, et al. Antitumor polysaccharides from mushrooms: a review on their isolation process, structural characteristics and antitumor activity[J]. Trends in Food Science & Technology, 2007, 18(1): 4-19
[21]	Zhang Y, Li S, Wang X, et al. Advances in lentinan: Isolation, structure, chain conformation and bioactivities[J]. Food Hydrocolloids, 2011, 25(2): 196-206
[22]	Ng T B. A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae)[J]. Gen Pharmacol, 1998, 30(1): 1-4
[23]	Sun Y. Structure and biological activities of the polysaccharides from the leaves, roots and fruits of Panax ginseng C.A. Meyer: An overview[J]. Carbohydrate Polymers, 2011, 85(3): 490-499
[24]	Wang B, Won S, Yu Z, et al. Free radical scavenging and apoptotic effects of Cordyceps sinensis fractionated by supercritical carbon dioxide[J]. Food and Chemical Toxicology, 2005, 43(4): 543-552
[25]	Xu H, Zhang Y, Zhang J, et al. Isolation and characterization of an anti-complementary polysaccharide D3-S1 from the roots of Bupleurum smithii[J]. International Immunopharmacology, 2007, 7(2): 175-182
[26]	Rios J L. Chemical constituents and pharmacological properties of Poria cocos[J]. Planta Med, 2011, 77(7): 681-691
[27]	Jin M, Zhao K, Huang Q, et al. Isolation, structure and bioactivities of the polysaccharides from Angelica sinensis (Oliv.) Diels: A review[J]. Carbohydrate Polymers, 2012, 89(3): 713-722
[28]	毛俊浩,吕志良. 白术多糖对小鼠淋巴细胞功能的调节[J]. 免疫学杂志, 1996, 12(4): 233-236
[29]	汤新慧. 白术多糖对小鼠免疫功能的影响[J]. 中医研究, 1998, 11(2): 7-9
[30]	孟慧玲,魏道武. 当归多糖的药理学研究新进展[J]. 甘肃中医, 2007, 20(1): 44-46

Immunomodulatory and Antitumor Activities of Polysaccharide from Chinese White Wax Scale

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通讯作者: 陈斌, bchen63@163.com

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Immunomodulatory and Antitumor Activities of Polysaccharide from Chinese White Wax Scale

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